diff --git a/meta-python/recipes-devtools/python/python3-protobuf_4.25.3.bb b/meta-python/recipes-devtools/python/python3-protobuf_4.25.3.bb
index 9695880d02..c7e1f3c3f2 100644
--- a/meta-python/recipes-devtools/python/python3-protobuf_4.25.3.bb
+++ b/meta-python/recipes-devtools/python/python3-protobuf_4.25.3.bb
@@ -36,3 +36,11 @@ DISTUTILS_INSTALL_ARGS += "--cpp_implementation"
 do_compile:prepend:class-native () {
     export KOKORO_BUILD_NUMBER="1"
 }
+
+do_install:append () {
+    # Remove useless and problematic .pth file. python3-protobuf is installed in the standard
+    # location of site packages. No need for such .pth file.
+    # NOTE: do not drop this removal until the following issue in upstream cpython is resolved:
+    # https://github.com/python/cpython/issues/122220
+    rm -f ${D}${PYTHON_SITEPACKAGES_DIR}/protobuf-*-nspkg.pth
+}