diff --git a/meta/conf/distro/include/time64.inc b/meta/conf/distro/include/time64.inc
index 99eb06dc0f..c6a3b682c2 100644
--- a/meta/conf/distro/include/time64.inc
+++ b/meta/conf/distro/include/time64.inc
@@ -11,6 +11,9 @@ GLIBC_64BIT_TIME_FLAGS:pn-glibc-tests = ""
 # both 32 and 64 bit file APIs.  But it does not handle the time side?
 # Needs further investigation
 GLIBC_64BIT_TIME_FLAGS:pn-pipewire = ""
+# Pulseaudio override certain LFS64 functions e.g. open64 and intentionally
+# undefines _FILE_OFFSET_BITS, which wont work when _TIME_BITS=64 is set
+GLIBC_64BIT_TIME_FLAGS:pn-pulseaudio = ""
 GLIBC_64BIT_TIME_FLAGS:pn-gcc-sanitizers = ""
 
 INSANE_SKIP:libstd-rs[_usr_lib_rustlib_armv7-poky-linux-gnueabihf_lib_libstd.so] = "clock_gettime gettime fcntl fstat64 fstatat64 getsockopt ioctl lstat64 nanosleep prctl recvmsg sendmsg setsockopt stat64"